Karlene has been given to about 4,167 people in the United States since 1880. It was most common in 1959, which makes it a midcentury name.
Its best year was 1959, when 104 babies were given the name, ranking 1050th. The typical living American called Karlene is about 64 years old today.
Source: US Social Security Administration, national and state name files, 2025 release, and the Office for National Statistics for England and Wales. Etymology researched and written by our editors. Living-population and median-age figures are our own estimates, described in the methodology.